Publications

Results presented/published

2023

The effect of pregnancy on the pharmacokinetics of total and unbound dolutegravir and its main metabolite in women living with HIV

2022

Publication in CID:  Tenofovir Alafenamide Plasma Concentrations Are Reduced in Pregnant Women Living With Human Immunodeficiency Virus (HIV): Data From the PANNA Network.

2021

Publication in AIDS:  First pharmacokinetic data of bictegravir in pregnant women living with HIV

Publication in CPT Pharmacometrics Syst Pharmacol:  A population pharmacokinetics analysis assessing the exposure of raltegravir once-daily 1200 mg in pregnant women living with HIV

Oral presentation  at 21st edition of the International Workshop on Clinical Pharmacology of Antiviral Therapy:  Tenofovir alafenamide plasma concentrations are reduced by half in pregnant women living with HIV: data from the PANNA Network.

Poster at 21st edition of the International Workshop on Clinical Pharmacology of Antiviral Therapy:  FIRST REPORTED USE OF BICTEGRAVIR IN TWO PREGNANT WOMEN LIVING WITH HIV.

2020

Publication in CID: Clinically significant lower elvitegravir exposure during third trimester of pregnant patients living with HIV: data from the PANNA study.

Publication in CID: The Effect of Pregnancy on the Pharmacokinetics of Total and Unbound Dolutegravir and Its Main Metabolite in Women Living With Human Immunodeficiency Virus .

Publication in AIDS: Low raltegravir transfer into the breastmilk of a woman living with HIV.

Publication in CPT Pharmacometrics Syst Pharmaccol.: A population pharmacokinetics analysis assessing the exposure of raltegravir once-daily 1200mg in pregnant women living with HIV.

Publication in The Journal of Clinical Pharmacology: Effect of Pregnancy and Concomitant Antiretrovirals on the Pharmacokinetics of Tenofovir inWomen With HIV Receiving Tenofovir Disoproxil Fumarate-Based Antiretroviral Therapy VersusWomen With HBV Receiving Tenofovir Disoproxil Fumarate Monotherapy.

Oral presentation at 21st edition of the International Workshop on Clinical Pharmacology of Antiviral Therapy: Subtherapeutic Raltegravir Exposure in Pregnant Women Living with HIV Treated with 1200mg Once-Daily 

2019

Publication in Antivir Ther: Efavirenz pharmacokinetics during pregnancy and infant washout.

Publication in J Antimicrob Chemother: Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling.

Poster at CROI:  Dolutegravir pharmacokinetics during pregnancy and postpartum 

Oral presentation at 9th edition of the International Workshop on HIV & Women:  Dolutegravir pharmacokinetics during pregnancy and postpartum 

2018

Publication in Antiviral Therapy: Efavirenz pharmacokinetics during pregnancy and infant washout.

Oral presentation at 19th edition of the International Workshop on Clinical Pharmacology of Antiviral Therapy:  Elvitegravir pharmacokinetics during pregnancy and postpartum 

Oral presentation at 19th edition of the International Workshop on Clinical Pharmacology of Antiviral Therapy:  First report of dolutegravir unbound plasma concentrations during pregnancy in HIV-positive women 

Publication related to PANNA, using PANNA data in Clin Pharmacokinet:  Prediction of Fetal Darunavir Exposure by Integrating Human Ex-Vivo Placental Transfer and Physiologically Based Pharmacokinetic Modeling 

Publication related to PANNA, using PANNA data in Clin Pharmacokinet:  A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women 

2017 

Publication in CID: Lowered rilpivirine exposure during the third trimester of pregnancy in Human Immunodeficiency Virus Type 1-infected women.

Oral presentation at 18th edition of the International Workshop on Clinical Pharmacology of Antiviral Therapy: A comparison of the pharmacokinetics of dolutegravir in pregnancy and postpartum (O_07)

Poster at CROI: Substantially lower rilpivirine plasma concentrations during pregnancy.

2016 

Publication in Front Pharmacol: Etravirine Pharmacokinetics in HIV-Infected Pregnant Women.

Publication in AIDS: Substantially lowered dolutegravir exposure in a treatment-experienced perinatally HIV-1-infected pregnant woman.

Publication in AIDS: First reported use of elvitegravir and cobicistat during pregnancy.

Publication in AIDS: The pharmacokinetics of abacavir 600 mg once daily in HIV-1-positive pregnant women.

One posters and one oral presentation at 17th edition of the International Workshop on Clinical Pharmacology of HIV & Hepatitis Therapy: Timing of the postpartum curve in pharmacokinetic studies in pregnancy should not be too early (O_3) and Is pregnancy a barrier to the proposed lower dose of efavirenz? P_26

One poster at CROI 2016: A Comparison of the Pharmacokinetics of Efavirenz During Pregnancy and Postpartum.

Publication related to PANNA, using PANNA data in J Antimicrob Chemother: Placental transfer of the HIV integrase inhibitor dolutegravir in an ex vivo human cotyledon perfusion model

2015

Publication in Clinical Pharmacokinetics: Physiologically Based Modelling of Darunavir/Ritonavir Pharmacokinetics During Pregnancy.

Publication in CID: Maraviroc Pharmacokinetics in HIV-1-Infected Pregnant Women.

Publication in CID: Raltegravir in HIV-1-Infected Pregnant Women: Pharmacokinetics, Safety, and Efficacy.

Four posters at 16th edition of the International Workshop on Clinical Pharmacology of HIV & Hepatitis Therapy: Darunavir population pharmacokinetics in pregnancy; Ritonavir pharmacokinetics in pregnancy; Rilpivirine pharmacokinetics in pregnancy; Abacavir pharmacokinetics in pregnancy.

One poster at CROI 2015: Etravirine Pharmacokinetics During Pregnancy and Postpartum.

2014

Publication in JAC: Pharmacokinetics of total and unbound darunavir in HIV-1-infected pregnant women.

Publication in AVT: Atazanavir exposure is effective during pregnancy, regardless of tenofovir use.

Three posters were presented at CROI 2014: darunavir 800/100mg QD, raltegravir and atazanavir

Publication in AIDS: Pharmacokinetics, safety and transplacental passage of rilpivirine in pregnancy: two cases .

2013

Data on maraviroc were presented as a poster (collaboration with IMPAACT) at the 20th Conference on Retroviruses and Opportunistic Infections (CROI), Atlante, GA PANNA/IMPAACT poster maraviroc CROI 2013 .

Publication in AIDS: The pharmacokinetics, safety and efficacy of tenofovir and emtricitabine in HIV-1 infected pregnant women.

2012

Data on darunavir, atazanavir and ritonavir were presented as a poster at the 19th Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, WA PANNA poster darunavir, atazanavir, ritonavir CROI 2012. Data on tenofovir were presented as a poster at the 13th International Workshop on Clinical Pharmacology of HIV Therapy, Barcelona PANNA poster PKworkshop 2012.

2011

Preliminary data raltegravir, poster presented at the 12th International Workshop on Clinical Pharmacology of HIV Therapy, Miami, FL raltegravir_poster_PKworkshop_2011.